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Hydrocodone, also known as dihydrocodeinone, is a semi-synthetic opioid used to treat pain and as a cough suppressant.[10] It is taken by mouth.[10] Typically, it is dispensed as the combination acetaminophen/hydrocodone or ibuprofen/hydrocodone for pain severe enough to require an opioid[11][12][13] and in combination with homatropine methylbromide to relieve cough.[10] It is also available by itself in a long-acting form sold under the brand name Zohydro ER, among others, to treat severe pain of a prolonged duration.[10][14] Hydrocodone is a controlled drug: in the United States, it is classified as a Schedule II Controlled Substance.
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Product Overview
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Chemical Name: 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one
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CAS Number: 125-29-1
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Molecular Formula: C₁₈H₂₁NO₃
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Appearance: White to off-white crystalline powder
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Purity: Typically ≥98%
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Packaging: Available in various quantities, including bulk options
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Hydrocodone powder is predominantly used in the synthesis of hydrocodone combination products, which are prescribed for the management of severe pain and as a cough suppressant. These combination products are formulated with other analgesics, such as acetaminophen or ibuprofen, to enhance efficacy. Hydrocodone powder suppliers Texas.
In research settings, hydrocodone is utilized to study its pharmacological properties, including its analgesic and antitussive effects. It serves as a reference standard in analytical testing and quality control processes. Hydrocodone powder suppliers California.
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Common side effects include dizziness, sleepiness, nausea, and constipation.[10] Serious side effects may include low blood pressure, seizures, QT prolongation, respiratory depression, and serotonin syndrome.[10] Rapidly decreasing the dose may result in opioid withdrawal.[10] Use during pregnancy or breastfeeding is generally not recommended.[15] Hydrocodone is believed to work by activating opioid receptors, mainly in the brain and spinal cord.[10] Hydrocodone 10 mg is equivalent to about 10 mg of morphine by mouth.[16]
Hydrocodone was patented in 1923, while the long-acting formulation was approved for medical use in the United States in 2013.[10][17] It is most commonly prescribed in the United States, which consumed 99% of the worldwide supply as of 2010.[18] In 2018, it was the 402nd most commonly prescribed medication in the United States, with more than 400,000 prescriptions.[19] Hydrocodone is a semi-synthetic opioid, converted from codeine[20][21] or less often from thebaine.[22] Production using genetically engineered yeasts has been developed but is not used commercially.
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Medical uses
Hydrocodone is used to treat moderate to severe pain. In liquid formulations, it is used to treat coughing.[10] In one study comparing the potency of hydrocodone to that of oxycodone, it was found that it took 50% more hydrocodone to achieve the same degree of miosis (pupillary contraction).[26] The investigators interpreted this to mean that oxycodone is about 50% more potent than hydrocodone.
However, in a study of emergency department patients with fractures, it was found that an equal amount of either drug provided about the same degree of pain relief, indicating that there is little practical difference between them when used for that purpose.[27] Some references state that the analgesic action of hydrocodone begins in 20–30 minutes and lasts about 4–8 hours.[28] The manufacturer’s information says onset of action is about 10–30 minutes and duration is about 4–6 hours.[29] Recommended dosing interval is 4–6 hours. Hydrocodone reaches peak serum levels after 1.3 hours.
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Hydrocodone is one kind of opioid pain reliever.
Hysingla ER and Zohydro ER are two examples of extended-release hydrocodone formulations that are used to constantly treat extreme pain. Extended-release hydrocodone is not intended to relieve pain.
In addition to the uses listed in this pharmacological guide, hydrocodone has further uses.
Hydrocodone is used to treat moderate to severe pain. contains both an opioid analgesic (hydrocodone) and a non-opioid analgesic (acetaminophen). The effects of hydrocodone on the brain change how your body experiences and responds to pain. Paracetamol can also be used to reduce the temperature. LegitGrams
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