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Naloxone Powder
1.Name:Naloxone
2.Appearance:White powder
3.Grade: Pharmaceutical grade
4.CAS No.:465-65-6
5.Molecular Formula:C19H21NO4
6.Molecular Weight:327.37
7.Payment Method:T/T Western Union/Alibaba Online/Visa
8.Certificates: FDA,Organic,Kosher, ISO, HALAL, HACCP, GMP
9.Transport Package:1kg Aluminum Foil Bag/25kg Drum
10.Factory situation:Two Factories & Three production lines.GMP standard workshop & two independent laboratories.
11.Storage method:Dry and cool place
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Naloxone Powder Product Details
Naloxone powder, a potent opioid antagonist, is a critical pharmaceutical raw material utilized in the formulation of various life-saving medications. As a critical part in the treatment of narcotic excess, naloxone acts quickly to switch the perilous impacts of narcotics on the focal sensory system. At Salispharm, we pride ourselves on being a premier supplier of pharmaceutical raw materials, with a specialization in providing high-quality the powder to global pharmaceutical manufacturers. Our product is available in pure form, ensuring efficacy and reliability in every application. Salispharm offers versatile support for various dosage forms, enabling seamless integration into a wide range of pharmaceutical formulations. purchase fentanyl hcl online
Why Choose Us?
When it comes to sourcing pharmaceutical raw materials, Salispharm stands out as the preferred choice for discerning manufacturers worldwide. Here’s why:
- Mature R&D Team: Our seasoned research and development team continuously innovates to ensure the highest quality standards and optimal performance of our products.
- GMP Factory: Operating within a Good Manufacturing Practice (GMP) compliant facility, we adhere to stringent quality control measures throughout the manufacturing process, guaranteeing product purity and consistency.
- Large Inventory: With a vast inventory of buprenorphine nalox, we can accommodate orders of varying scales promptly, ensuring uninterrupted production for our clients.
- Complete Certificates: Salispharm products are backed by a comprehensive array of certifications, including FDA approval, HALAL certification, IS0 accreditation, CCRE5 compliance, organic USDA certification, organic certification, and EU Organic certification.
- OEM Support: We offer extensive Original Equipment Manufacturer (OEM) services, facilitating customized dosage formulations tailored to specific client requirements. Our flexibility extends to selling finished products, providing comprehensive solutions for pharmaceutical manufacturers.
- Fast Delivery: We understand the importance of timely delivery in the pharmaceutical industry. Our efficient logistics network ensures swift transportation, minimizing lead times and optimizing production schedules. Buy Naloxone naltrexone Powder online
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COA of Naloxone Powder
| Items | Standards | Results |
|---|---|---|
| Appearance | White or off-white powder | Off-white powder |
| Identification | By HPLC | Complies |
| Melting Point | 120ºC~130ºC | 126ºC |
| Loss on Drying | ≤1.00% | 0.21% |
| Heavy Metals | ≤ 10ppm | Complies |
| Sulfated Ash | ≤ 0.10% | 0.03% |
| Content | 17.5%~19.5% | 19.3% |
| As | ≤ 0.1ppm | 0.09ppm |
| Pb | ≤ 3.0ppm | 0.50ppm |
| Cd | ≤ 0.1ppm | 0.10ppm |
| Hg | ≤ 0.1ppm | 0.10ppm |
| Microbiological | Coliforms:Negative | Negative |
| Salmonella: Negative | Negative | |
| Total plate count: ≤1000 CFU/g | Complies | |
| Yeast&Mold: ≤50 CFU/g | Complies | |
| Related Substances | Impurity A: ≤0.30% | 0.18% |
| Other unknown impurity: ≤0.10% | 0.07% | |
| Total Impurities: ≤0.50% | 0.42% | |
| Assay | ≥ 98.0% | 99.50% |
Use of Naloxone Powder
The powder fills in as a critical mediation in instances of narcotic excess, applying its pharmacological impacts through cutthroat opposition at narcotic receptors. When managed speedily, naloxone actually switches the respiratory wretchedness and focal sensory system melancholy actuated by narcotic excess, accordingly reestablishing ordinary breathing and awareness. Its quick beginning of activity and brief term make it fundamental in crisis clinical settings, where quick mediation can mean the contrast among life and demise.
Application of Naloxone Powder
The versatility of naloxone powder extends beyond its role as an opioid overdose antidote. It finds application in various medical settings and scenarios, including:
- Emergency Medicine: Naloxone is a foundation of crisis clinical conventions for the administration of narcotic excess, whether in clinics, ambulances, or local area settings.
- Chronic Pain Management: In persistent agony the board regimens including narcotic analgesics, naloxone might be co-formed to moderate the gamble of narcotic actuated respiratory discouragement and go too far.
- Addiction Treatment: Naloxone is necessary to prescription helped treatment programs for narcotic use problem, where it forestalls backslide and go too far during narcotic detoxification and support treatment.
- Anesthesia: Naloxone might be utilized intraoperatively to neutralize narcotic incited respiratory melancholy and sedation, guaranteeing patient wellbeing during surgeries.
Dosage and Usage
The measurement and organization of the powder shift contingent upon the clinical situation and the patient’s reaction to narcotic excess. Regularly regulated through intravenous, intramuscular, subcutaneous, or intranasal courses, naloxone dosing means to accomplish quick inversion of narcotic harmfulness while limiting unfavorable impacts. Medical services experts ought to go through preparing in the legitimate organization methods and be ready to change measurements in view of the patient’s clinical status and reaction.
Quality Standards and Certification
Salispharm is committed to upholding the highest quality standards and ensuring compliance with regulatory requirements. Our buprenorphine nalox meets the following certifications:
- FDA Approval
- HALAL Certification
- ISO Accreditation
- CCRE5 Compliance
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- Organic Certification
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These certificates bear witness to the immaculateness, wellbeing, and adequacy of our items, giving confirmation to drug producers and end-clients the same.
Packaging and Transportation
To preserve the integrity and potency of our product, we employs robust packaging materials and stringent handling protocols. Items are safely bundled as per industry best practices to forestall tainting, corruption, or harm during transportation. We offer adaptable transportation choices custom-made to our clients’ requirements, guaranteeing opportune conveyance to objections around the world.
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Naloxone Hydrochloride Dihydrate Powder
Naloxone Hydrochloride Dihydrate Powder
| Product | Naloxone Hydrochloride Dihydrate Powder |
| CAS No. | 51481-60-8 |
| Appearance | Powder/Liquid |
| Purity | ≥ 99% |
| APS | 1-5µM (Can be customized) |
| Ingredient | C19H21NO4 · HCl · 2H2O |
| Product Codes | NCZ-AN-533/23 |
Naloxone Hydrochloride Dihydrate Powder Description:
Naloxone Hydrochloride Dihydrate Powder one of the numerous advanced ceramic materials manufactured by Nanochemazone. Nanochemazone produces too many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. Typical and custom packaging is available. Additional technical, research and safety (MSDS) information are available. Please request a quote above for more information on lead time and pricing.
Naloxone Hydrochloride Dihydrate Related Information
Naloxone, sold under the brand name Narcan among others, is an opioid antagonist, a medication used to reverse or reduce the effects of opioids.[14] For example, it is used to restore breathing after an opioid overdose.[14] Effects begin within two minutes when given intravenously, five minutes when injected into a muscle,[14] and ten minutes as a nasal spray.[15] Naloxone blocks the effects of opioids for 30 to 90 minutes.[16][17]
Administration to opioid-dependent individuals may cause symptoms of opioid withdrawal, including restlessness, agitation, nausea, vomiting, a fast heart rate, and sweating.[14] To prevent this, small doses every few minutes can be given until the desired effect is reached.[14] In those with previous heart disease or taking medications that negatively affect the heart, further heart problems have occurred.[14] There is limited data on naloxone’s safety during pregnancy.[18] Naloxone is a non-selective and competitive opioid receptor antagonist.[7][19] It reverses the depression of the central nervous system and respiratory system caused by opioids.[14][20][17]
Naloxone was patented in 1961 and approved for opioid overdose in the United States in 1971.[21][22] It is on the World Health Organization’s List of Essential Medicines.
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Where is Naloxone Commonly Used?
Naloxone is used in various settings where drug overdoses are likely, making it essential for saving lives in critical situations.
Medical uses
Opioid overdose
Naloxone is useful in treating both acute opioid overdose and respiratory or mental depression due to opioids.[14] Whether it is useful in those in cardiac arrest due to an opioid overdose is unclear.[24]
It is included as a part of emergency overdose response kits distributed to heroin, fentanyl, and other opioid drug users, and to emergency responders. This has been shown to reduce rates of deaths due to overdose.[25] A prescription for naloxone is recommended if a person is on a high dose of opioid (>100 mg of morphine equivalence/day), is prescribed any dose of opioid accompanied by a benzodiazepine, or is suspected or known to use opioids nonmedically.[26] Prescribing naloxone should be accompanied by standard education that includes preventing, identifying, and responding to an overdose; rescue breathing; and calling emergency services.[27]
Distribution of naloxone to individuals likely to encounter people who overdose is one aspect of harm reduction strategies.[28]
However, with opioids that have longer half-lives, respiratory depression returns after naloxone has worn off; therefore, adequate dosing and continuous monitoring may be necessary.[29]
Clonidine overdose
Naloxone can also be used as an antidote in an overdose of clonidine, a medication that lowers blood pressure.[30] Clonidine overdoses are of special relevance for children, in whom even small doses can cause significant harm.[31] However, there is controversy regarding naloxone’s efficacy in treating the symptoms of clonidine overdose, namely slow heart rate, low blood pressure, and confusion/somnolence.[31] Case reports that used doses of 0.1 mg/kg (maximum of 2 mg/dose) repeated every 1–2 minutes (10 mg total dose) have shown inconsistent benefit.[31] As the doses used throughout the literature vary, it is difficult to form a conclusion regarding the benefit of naloxone in this setting.[32] The mechanism for naloxone’s proposed benefit in clonidine overdose is unclear. Still, it has been suggested that endogenous opioid receptors mediate the sympathetic nervous system in the brain and elsewhere in the body.[32]
Preventing recreational opioid use
Naloxone is poorly absorbed when taken orally or sublingually, so it is often added to oral or sublingual opioid preparations, including buprenorphine and pentazocine, so that when swallowed or taken sublingually, only the non-naloxone opioid has an effect.[14][33] However, if the combination is injected (such as by dissolving a pill or sublingual strip in water), the naloxone is believed to block the effect of the other opioid.[14][33] This combination is used to prevent non-medical use.[33]
However, SAMHSA‘s clinical guidelines state that if the combination of buprenorphine and naloxone is injected by a regular user of buprenorphine or buprenorphine/naloxone, then the buprenorphine would still produce an agonist effect but the naloxone would fail to produce an antagonist effect. This is because the amount of naloxone that would be required to block the buprenorphine after injection is much larger than the amount that is contained in buprenorphine/naloxone (Suboxone) pills and strips.[34] If someone who is not physically dependent on opioids were to inject the buprenorphine/naloxone combination, then the effects of the buprenorphine may at most be slightly lessened, but the individual would still be expected to experience euphoric effects.[34]
Other uses
A 2003 meta-analysis of existing research showed naloxone to improve blood flow in patients with shock, including septic, cardiogenic, hemorrhagic, or spinal shock, but could not determine if this reduced patient deaths.[35]
Oral naloxone has been used for opioid-induced constipation (OIC). A 2018 meta-analysis cites 5 studies that tests it for this purpose. It found that medical treatment for OIC can be more efficacious than placebo, but did not look into the effect of individual treatments such as naloxone. As a result, no conclusion can be drawn from the study on naloxone’s effectiveness for OIC.[36]
Special populations
Pregnancy and breastfeeding
There are no adequate and well-controlled studies of the naloxone’s use in pregnant women, much of the information on naloxone in pregnancy comes from studies on the use of naloxone and buprenorphine together, rather than the study of naloxone on its own.[2][18] Although one study showed a possible link to preterm labor and low birth weight, but once again this study was done on women with opioid use disorder who were taking Suboxone, no studies have been done to see if treatment with naloxone for an opioid overdose can increase the chance of pregnancy-related problems.
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