Buy N-isopropylbenzylamine Cas 102-97-6
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N-isopropylbenzylamine is a compound that has appeared in chemical literature often playing an intermediary role in applications of experimental synthesis and novel organic transformations. Despite having limited documented uses, it is most well known for having previously come to the attention of the DEA due to being used by illicit methamphetamine manufacturers as a diluent of or substitute for methamphetamine, with many recorded sightings occurring in the years 2007–2008. It not known to be a controlled substance in any other jurisdiction. Isopropylbenzylamine is not thought to have any stimulant effects in its own right, though anecdotal reports suggest that it may be associated with side effects such as headaches and confusion which are not typically associated with methamphetamine itself. The toxicity of N-isopropylbenzylamine has been studied as of 2022 and it has been found to produces toxicity via increasing nitric oxide in vitro. In this study, in vitro toxicity of N-isopropylbenzylamine and its toxicity-related targets were investigated in SN4741, SH-SY5Y or PC12 cell lines that model neurons. The study sounds an alarm for methamphetamine users and warns of the dangers of N-isopropylbenzylamine for public health. Buy N-isopropylbenzylamine Cas 102-97-6
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Furthermore, n-isopropylbenzylamine has been extensively studied for its potential applications in the field of medicine. Researchers have found that this compound exhibits promising antimicrobial properties, making it a potential candidate for the development of new antibiotics. Its ability to inhibit the growth of various bacteria and fungi has sparked interest in its use as a therapeutic agent against infectious diseases.
In addition to its antimicrobial properties, n-isopropylbenzylamine has also shown potential as an analgesic. Studies have demonstrated its ability to reduce pain and inflammation, making it a possible alternative to traditional pain medications. Its unique mechanism of action targets specific receptors in the central nervous system, providing effective pain relief without the risk of addiction or tolerance development.
Moreover, n-isopropylbenzylamine has been investigated for its potential use in the treatment of neurological disorders. Preliminary studies have shown that this compound has neuroprotective properties, which could be beneficial in conditions such as Alzheimer’s disease and Parkinson’s disease. By preventing neuronal damage and promoting cell survival, n-isopropylbenzylamine holds promise as a therapeutic agent for these debilitating conditions.
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Isopropylbenzylamine crystal CAS 102-97-6, also known as isopropylbenzylamine or N-Benzylisopropylamine, is a white transparent crystal with no odor. At room temperature, it appears as a solid state and has a certain degree of volatility. It can be used as an intermediate in the synthesis of pharmaceutical compounds, as well as a precursor in the production of some drugs. Due to its similarity in appearance and physical properties to methamphetamine, DEA has recently been considered. It is a commonly used organic base and an important raw material for organic synthesis, commonly used as an intermediate or drug precursor in the pharmaceutical industry. Mainly used as an organic intermediate, it can be used to synthesize other organic compounds. In addition, it can also be used in fields such as rust inhibitors. These applications make N-benzylisopropylamine have broad application prospects in industries such as chemical, pharmaceutical, and coatings.
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CAS 102-97-6, N-Isopropylbenzylamine(Short for N-ISO)
Three specifications:
I. Pure N-ISO(Melting point 200 degree)
3 shapes of crystal from the right 1st to 3rd, it has smell but the size of crystal is the biggest.
II. N-ISO mixed with MSM(CAS 67-71-0) (Melting point 180 degree)
The left 2ndis it, the size of crystal, smell and MP are all in medium.
III. N-ISO mixed with MSM(CAS 67-71-0) (Melting point 170 degree)
The left 1st is it, the size of crystal, smell and MP are all in min.
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What is isopropylbenzylamine used for ? It is a common organic base, an important organic synthesis raw material that can be used as an intermediate for the synthesis of compounds, and also as a precursor for the production of certain drugs. N-benzylisopropylamine and magnesium form amine adducts at room temperature in toluene.Bis (cyclopentadienyl) magnesium was prepared and characterized with N-benzyl isopropylamine as ligand. It is also used in the synthesis of N-benzyl isopropylamine.
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Experimental Synthesis and Novel Organic Transformations
Field: Organic Chemistry
Results: The outcomes of these reactions would vary greatly depending on the specific reactions being performed.
Preparation and Characterization of Bis (Cyclopentadienyl)Magnesium
Field: Inorganic Chemistry
Application: N-Isopropylbenzylamine was used as a ligand in the preparation and characterization of bis (cyclopentadienyl)magnesium.
Synthesis of N-Benzylideneisopropylamine-N-Oxide
Application: N-Isopropylbenzylamine was also used in the synthesis of N-Benzylideneisopropylamine-N-Oxide.
Results: The result would be the successful synthesis of N-Benzylideneisopropylamine-N-Oxide.
Synthesis of Novel Bifunctional N,N-di-isopropylbenzylamineboronic Acid Catalysts
N-Isopropylbenzylamine-Induced Conditioned Place Preference
Field: Behavioral Neuroscience
N-Isopropylbenzylamine is an organic compound with the chemical formula C10H15N and a molecular weight of approximately 149.24 g/mol. It is a structural isomer of methamphetamine, sharing similar physical properties but differing in its chemical behavior and potential effects. This compound has garnered attention for its illicit use as a substitute or adulterant in methamphetamine production, particularly noted in reports from the Drug Enforcement Administration during the late 2000s .
Typical of amines. It can undergo:
- Reductive Amination: Synthesized from benzylamine and acetone, this process involves the reaction of an amine with a ketone or aldehyde in the presence of a reducing agent .
- Oxidation: It can be oxidized to form nitrones or other nitrogen-containing compounds, often mediated by hydrogen peroxide or other oxidizing agents .
The compound is also known to form explosive mixtures with air when subjected to intense heating, indicating its reactivity under certain conditions .
Recent studies have highlighted the biological activity of N-isopropylbenzylamine, particularly its neurotoxic effects. In vitro experiments have shown that it induces cell death in neuronal cell lines by increasing intracellular nitric oxide levels through the activation of neuronal nitric oxide synthase . The compound has been linked to side effects such as headaches and confusion among users, although its addictive potential remains unclear compared to methamphetamine .
The synthesis of N-isopropylbenzylamine can be achieved through several methods:
- Reductive Amination: Combining benzylamine with acetone in the presence of a reducing agent.
- Reduction of N-Isopropylbenzamide: This method involves reducing the corresponding amide to yield the amine product .
- Direct Alkylation: In some cases, alkylation reactions may be employed to introduce the isopropyl group onto benzylamine.
These methods highlight its role as an intermediate in organic synthesis and pharmaceutical applications.
Studies investigating the interactions of N-isopropylbenzylamine have focused on its neurotoxic effects and potential for abuse. Research indicates that it can produce conditioned place preference in animal models, suggesting some level of reinforcing properties similar to methamphetamine but at reduced efficacy . In vitro studies have demonstrated that it increases nitric oxide production, which correlates with observed cytotoxic effects on neuronal cells .
N-Isopropylbenzylamine shares structural similarities with several other compounds, particularly those related to amphetamines. Below is a comparison highlighting its uniqueness:
| Compound | Chemical Formula | Key Characteristics |
|---|---|---|
| Methamphetamine | C10H15N | Potent stimulant; high abuse potential; significant addiction risk |
| Benzylamine | C7H9N | Used as an intermediate; less potent than N-isopropylbenzylamine |
| N-Isopropylamphetamine | C11H17N | Structural analog; more potent stimulant properties |
| N,N-Dimethylbenzylamine | C10H15N | Similar structure; used in pharmaceuticals but less toxic |
N-Isopropylbenzylamine’s unique position arises from its use as an adulterant and its neurotoxic profile, distinguishing it from other compounds that may not exhibit similar levels of toxicity or illicit use.
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Reported as not meeting GHS hazard criteria by 1 of 49 companies. For more detailed information, please visit ECHA C&L website;
Of the 6 notification(s) provided by 48 of 49 companies with hazard statement code(s):;
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation];
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];
H335 (97.92%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure;
Respiratory tract irritation];
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
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Sanderson, R.M. Identification of N-methylbenzylamine hydrochloride, N-ethylbenzylamine hydrochloride, and N-isopropylbenzylamine hydrochloride. Microgram J. 6(1-2), 36-45 (2008).
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