Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Propiophenone (shorthand: benzoylethane or BzEt) is an aryl ketone. It is a colorless, sweet-smelling liquid that is insoluble in water, but miscible with organic solvents. It is used in the preparation of other compounds. Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Production
Propiophenone can be prepared by Friedel–Crafts reaction of propanoyl chloride and benzene. It is also prepared commercially by ketonization of benzoic acid and propionic acid over calcium acetate and alumina at 450–550 °C:[1]
- C6H5CO2H + CH3CH2CO2H → C6H5C(O)CH2CH3 + CO2 + H2O
Ludwig Claisen discovered that α-methoxystyrene forms this compound when heated for an hour at 300 °C (65% yield).[2][3]
Uses
It is an intermediate in the synthesis of the pharmaceuticals phenmetrazine and propoxyphen.[1][4][5]
Other drugs made from propiophenone include the following: PDM-35, Eprazinone, Methcathinone (leading to ephedrine), Trimebutine, Amfepramone, Diphepanol, Metamfepramone, Etoxadrol, Hydroxyphenamate, Phendimetrazine, Iminophenimide, Bencisteine, Flumecinol, Pyrroliphene, Perisone,
In the Hoch-Campbell ethylenimine synthesis, a compound called 3-Methyl-2,2-diphenylaziridine [7764-13-8] was made.
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Buy Propiophenone (benzoylethane BzEt) Cas 93-55-0
Propiophenone is a drug that belongs to the class of hydroxypropiophenones and is used in combination preparations. It is an intermediate in the synthesis of other drugs, such as propofol. Propiophenone reacts with trifluoromethanesulfonic acid and hydrochloric acid to form the corresponding salt. The reaction mechanism starts with the addition of one molecule of hydroxyl group to one molecule of propiophenone. This leads to an acylation reaction between propiophenone and ethylene diamine, which produces a methyl ketone. The next step is the formation of an imine from a second molecule of ethylene diamine and another molecule of propiophenone, which then reacts with another molecule of ethylene diamine in an asymmetric synthesis process. !–
Propiophenone, also known as Ethyl phenyl ketone, is an aryl ketone used as an intermediate in the synthesis of organic compounds and pharmaceuticals; it is also used in the synthesis of aryl alkenes. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
Synonyms: 1-Phenyl-1-propanone ; Ethyl Phenyl Ketone
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