Buy Tapentadol Hydrochloride CAS-175591-09-0
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Tapentadol Hydrochloride (CAS NO : 175591-09-0)
Tapentadol, sold under the brand names Nucynta and Palexia among others, is a synthetic opioid analgesic with a dual mode of action as a highly selective full agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI).[6] Tapentadol is used medically for the treatment of moderate to severe pain.[2] It is highly addictive and is a commonly abused drug.[2][8][9][10]
Frequently reported adverse effects include euphoria, constipation, nausea, vomiting, headaches, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating.[11] More severe adverse reactions can occur, including addiction and dependence, substance abuse, respiratory depression, and an elevated risk of serotonin syndrome.[12][13] Concurrent use of tapentadol with serotonergic drugs or central nervous system depressants – including alcohol, cannabis, benzodiazepines, and other opioids – can heighten the risks of excessive serotonin accumulation, profound sedation, dangerously slowed breathing and death.[9][14]
Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours.[15] Tapentadol is taken by mouth, and is available in immediate-release and controlled-release formulations.[16] Tapentadol’s combined mechanism of action is often compared to that of tramadol.[15] Unlike tramadol, tapentadol is not metabolised by cytochrome P450 enzymes, but rather through glucuronidation.[17] Due to this, tapentadol has fewer interactions with other medications and fewer side effects when compared with tramadol.[17]
Like tramadol, tapentadol affects both the opioid system and the norepinephrine system to relieve pain.[18] Unlike tramadol, it has only weak effects on the reuptake of serotonin and is a significantly more potent opioid with no known active metabolites.[15][19] The potency of tapentadol is somewhere between that of tramadol and morphine,[20] with an analgesic efficacy comparable to that of oxycodone despite a lower incidence of side effects.[6] The CDC Opioid Guidelines Calculator estimates a conversation rate of 50mg of tapentadol equaling 10 mg of oral oxycodone in terms of opioid receptor activation.[21]
In the late 1980s, Grünenthal developed tapentadol to improve on tramadol,[22] which they had created in 1962.[23] Their goal was to design a molecule that minimized serotonin activity, strongly activated the μ-opioid receptor, inhibited norepinephrine reuptake, and worked without metabolic activation.[22] The result was tapentadol. Due to the high risk of addiction, substance misuse, and dependence,[24][10][14] tapentadol is a Schedule II controlled substance in the United States,[25] a Schedule 8 controlled drug in Australia,[26] and a Class A controlled substance in the United Kingdom.
Drug EntryTapentadol
Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.2,3
Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA on August 26, 2011.6 Used in the management of pain, tapentadol is typically reserved for patients who have limited alternative treatment options.
Monoisotopic: 257.154642102
InChI
IUPAC Name
SMILES
External Links
Medical use
Tapentadol is used for the treatment of moderate to severe pain for both acute (following e.g. injury or surgery) and chronic musculoskeletal pain. It is also specifically indicated for controlling the pain of diabetic neuropathy when around-the-clock opioid medication is required.
Extended-release formulations of tapentadol are not indicated for use in the management of acute pain and are instead indicated only for the relief of severe, disabling pain, that is long-term in nature and cannot be controlled by any other pharmacological means.
Tapentadol is pregnancy category C. There are no adequate and well-controlled studies of tapentadol in pregnant women, and tapentadol is not recommended for use in women during and immediately prior to labor and delivery.
There are no adequate and well-controlled studies of tapentadol in children.
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| Cas No. | 175591-09-0 | SDF | Download SDF |
| PubChem ID | 9838021 | Appearance | Powder |
| Formula | C14H24ClNO | M.Wt | 257.8 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol;hydrochloride | ||
| SMILES | CCC(C1=CC(=CC=C1)O)C(C)CN(C)C.Cl | ||
| Standard InChIKey | ZELFLGGRLLOERW-YECZQDJWSA-N | ||
| Standard InChI | InChI=1S/C14H23NO.ClH/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12;/h6-9,11,14,16H,5,10H2,1-4H3;1H/t11-,14+;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial. Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.879 mL | 19.3949 mL | 38.7898 mL | 77.5795 mL | 96.9744 mL |
| 5 mM | 0.7758 mL | 3.879 mL | 7.758 mL | 15.5159 mL | 19.3949 mL |
| 10 mM | 0.3879 mL | 1.9395 mL | 3.879 mL | 7.758 mL | 9.6974 mL |
| 50 mM | 0.0776 mL | 0.3879 mL | 0.7758 mL | 1.5516 mL | 1.9395 mL |
| 100 mM | 0.0388 mL | 0.1939 mL | 0.3879 mL | 0.7758 mL | 0.9697 mL |
| * Note: If you are in the process of experiment, it’s necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it’s can get a better solubility within lower of Concentrations. | |||||
Tapentadol Hydrochloride
Tapentadol Hydrochloride Trade Information
About Tapentadol Hydrochloride
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Tapentadol is a prescription opioid medication primarily used to treat moderate to severe pain. It works by binding to the opioid receptors in the brain and blocking pain signals.
If you have a valid prescription for tapentadol, you can purchase it online from a reputable pharmacy that requires a valid prescription before dispensing medication. However, exercising caution when purchasing medication online is important, as many illegitimate websites and sellers may sell counterfeit or dangerous medications.
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I cannot encourage or endorse purchasing any prescription medication without a valid prescription from a licensed healthcare professional. It is important to always consult with a doctor or a licensed healthcare provider before taking any medication.
That said, Tapentadol 100mg is a prescription medication for treating moderate to severe pain. It works by binding to the opioid receptors in the brain and blocking pain signals.
Tapenta 100 mg
Tapenta 100mg is a prescription medication that contains tapentadol as its active ingredient. It is primarily used to treat moderate to severe pain, such as pain caused by surgery or injury, chronic pain, and pain associated with arthritis.
Tapentadol is an opioid medication that works by binding to the opioid receptors in the brain and spinal cord, which helps to block pain signals and provide pain relief. It is classified as a Schedule II controlled substance, which means it has a high potential for abuse and dependence.
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A Tapentadol Hydrochloride supplier is an individual or a company that provides Tapentadol Hydrochloride active pharmaceutical ingredient (API) or Tapentadol Hydrochloride finished formulations upon request. The Tapentadol Hydrochloride suppliers may include Tapentadol Hydrochloride API manufacturers, exporters, distributors and traders.
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3-[(1r,2r)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride, (Tapentadol HCl) is the hydrochloride salt of Tapentadol, a centrally acting synthetic analgesic. Tapentadol Hydrochloride combines μ-opioid receptor agonist activity with norepinephrine reuptake inhibition, providing effective management of moderate to severe acute and chronic pain. The compound Tapentadol Hydrochloride is preferred and supplied as a white to off-white crystalline powder, offering good solubility in water and common pharmaceutical solvents. I dual mechanism of action makes it a unique option in pain therapy, with reduced gastrointestinal side effects compared to traditional opioids. It is a CNS agent (therapeutic class) as Phenolic compound (chemical structure).
Tapentadol Hydrochloride is an acclaimed pharmaceutical intermediate and analgesic, known for its lavish purity (99%) and incomparable stability under recommended conditions. Presented as a white to off-white crystalline powder, this in-demand compound meets rigorous standardsIR and HPLC confirm its identity; related substances and microbial limits comply with pharmacopeial requirements. Excellent packaging in sealed HDPE containers preserves its efficacy and shelf life (24 months). Get It Now from trusted distributors, exporters, and manufacturers for reliable pharmaceutical applications. Odorless, with a bitter taste, it ensures precision and quality across medical sectors.
Application Areas and Uses of Tapentadol Hydrochloride
Tapentadol Hydrochloride is primarily utilized in pharmaceutical manufacturing as a highly effective analgesic. It serves as a key intermediate for synthesizing pain relief medications, offering excellent results in hospital, clinic, and laboratory settings. Its area of application spans both domestic and global markets, including research institutes and pharmaceutical production facilities, where incomparable efficacy and reliability are paramount for therapeutic innovations.
Main Domestic Market, Packaging, and Certifications
Tapentadol Hydrochlorides arrival in the main domestic market is supported by secure packaging in sealed HDPE containers, ensuring product integrity. Upon receiving a quotation and confirming a purchase order, buyers can expect certification compliance, including pharmacopeial standards and maximum permissible impurity levels. This product is sought after by wholesale distributors, exporters, suppliers, and traders, making its presence notable throughout pharmaceutical sectors in India and globally.
FAQs of Tapentadol Hydrochloride:
Q: How is Tapentadol Hydrochloride most commonly used in pharmaceutical applications?
A: Tapentadol Hydrochloride is predominantly employed as an analgesic in the development of pain management medications and serves as an essential intermediate in pharmaceutical synthesis.
Q: What certifications and standards does Tapentadol Hydrochloride comply with?
A: This compound adheres to pharmacopeial standards, with identification confirmed by IR and HPLC methods, and meets impurity and microbial limits as mandated by regulations.
Q: When should Tapentadol Hydrochloride be stored or handled with caution?
A: It should always be stored in a cool, dry place, away from light, and handled with caution due to its toxic properties if misused.
Q: Where can Tapentadol Hydrochloride be obtained in bulk for industrial or pharmaceutical use?
A: The compound is available for purchase from certified distributors, exporters, importers, manufacturers, suppliers, and traders specializing in pharmaceutical chemicals.
Q: What is the packaging process for Tapentadol Hydrochloride to ensure stability?
A: The product is packaged in sealed HDPE containers, designed to maintain stability and prevent contamination during storage and shipment.
Q: What is the main benefit of using Tapentadol Hydrochloride in medicine production?
A: Its lavish purity and stability contribute to the excellent efficacy of pain relief medications, ensuring consistent and safe therapeutic outcomes.
About Tapentadol Hydrochloride
Tapentadol Hydrochloride is an acclaimed pharmaceutical intermediate and analgesic, known for its lavish purity (99%) and incomparable stability under recommended conditions. Presented as a white to off-white crystalline powder, this in-demand compound meets rigorous standardsIR and HPLC confirm its identity; related substances and microbial limits comply with pharmacopeial requirements. Excellent packaging in sealed HDPE containers preserves its efficacy and shelf life (24 months). Get It Now from trusted distributors, exporters, and manufacturers for reliable pharmaceutical applications. Odorless, with a bitter taste, it ensures precision and quality across medical sectors.
Application Areas and Uses of Tapentadol Hydrochloride
Tapentadol Hydrochloride is primarily utilized in pharmaceutical manufacturing as a highly effective analgesic. It serves as a key intermediate for synthesizing pain relief medications, offering excellent results in hospital, clinic, and laboratory settings. Its area of application spans both domestic and global markets, including research institutes and pharmaceutical production facilities, where incomparable efficacy and reliability are paramount for therapeutic innovations.
Main Domestic Market, Packaging, and Certifications
Tapentadol Hydrochlorides arrival in the main domestic market is supported by secure packaging in sealed HDPE containers, ensuring product integrity. Upon receiving a quotation and confirming a purchase order, buyers can expect certification compliance, including pharmacopeial standards and maximum permissible impurity levels. This product is sought after by wholesale distributors, exporters, suppliers, and traders, making its presence notable throughout pharmaceutical sectors in India and globally.
FAQs of Tapentadol Hydrochloride:
Q: How is Tapentadol Hydrochloride most commonly used in pharmaceutical applications?
A: Tapentadol Hydrochloride is predominantly employed as an analgesic in the development of pain management medications and serves as an essential intermediate in pharmaceutical synthesis.
Q: What certifications and standards does Tapentadol Hydrochloride comply with?
A: This compound adheres to pharmacopeial standards, with identification confirmed by IR and HPLC methods, and meets impurity and microbial limits as mandated by regulations.
Q: When should Tapentadol Hydrochloride be stored or handled with caution?
A: It should always be stored in a cool, dry place, away from light, and handled with caution due to its toxic properties if misused.
Q: Where can Tapentadol Hydrochloride be obtained in bulk for industrial or pharmaceutical use?
A: The compound is available for purchase from certified distributors, exporters, importers, manufacturers, suppliers, and traders specializing in pharmaceutical chemicals.
Q: What is the packaging process for Tapentadol Hydrochloride to ensure stability?
A: The product is packaged in sealed HDPE containers, designed to maintain stability and prevent contamination during storage and shipment.
Q: What is the main benefit of using Tapentadol Hydrochloride in medicine production?
A: Its lavish purity and stability contribute to the excellent efficacy of pain relief medications, ensuring consistent and safe therapeutic outcomes. Buy Tapentadol Hydrochloride CAS-175591-09-0
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