Product name:Remifentanil
CAS: 132875-61-7
Molecular Formula: C20H28N2O5
Molecular Weight: 376.1998
Product description:Rui fentanyl fentanyl for mu opioid agonist, in 1 minute or so quickly in the human body to achieve blood-brain balance, is rapidly hydrolyzed in tissue and blood, so the work quickly, keep time is short, and distinct from other fentanyl analogs. The analgesic effect of fentanyl and its side effects are dose dependent, and hypnotics, inhaled anesthetics and benzodiazepines medicines have synergy. Rui fentanyl excitement of mu opioid receptors by naloxone can adersely affect. Rui fentanyl also can cause respiratory depression, skeletal muscle, such as chest wall muscle stiffness, nausea, vomiting, hypotension and bradycardia, etc., within the scope of the dose, role to strengthen with the increase of the dose.Used to maintain analgesia and anesthesia induction of general anesthesia.
Remifentanil, marketed under the brand name Ultiva is a potent, short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct to an anesthetic. Remifentanil is used for sedation as well as combined with other medications for use in general anesthesia. The use of remifentanil has made possible the use of high-dose opioid and low-dose hypnotic anesthesia, due to synergism between remifentanil and various hypnotic drugs and volatile anesthetics. Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7, Buy Remifentanil powder Cas 132875-61-7
Medical uses
Remifentanil is used as an opioid analgesic that has a rapid onset and rapid recovery time.[2] It has been used effectively during craniotomies,[3] spinal surgery,[4] cardiac surgery,[5] and gastric bypass surgery.[6] While opioids function similarly, with respect to analgesia, the pharmacokinetics of remifentanil[7] allows for quicker post-operative recovery.[8]
Remifentanil can be administered as part of an anesthesia technique called TIVA (total intravenous anesthesia) using computer controlled infusion pumps in a process called TCI (target controlled infusion). A target plasma concentration is entered as ng/mL into the pump, which calculates its infusion rate according to patient factors like age and weight. Induction levels of 40 ng/mL are commonly used, but it generally varies between 3–8 ng/mL. For certain surgical procedures that produce particularly strong stimuli a level of up to 15 ng/mL might be needed. The relatively short context-sensitive half-life of remifentanil allows the desired blood plasma level to be achieved quickly, and also for the same reason, recovery occurs quickly. This allows remifentanil to be used in unique circumstances such as cesarean section.[9]
Remifentanil’s short context-sensitive half-life makes it ideal for intense pain of short duration. As such, it has been used for analgesia in labor successfully; however, it is not as effective as epidural analgesia.[10]
In combination with propofol, remifentanil is used for anesthesia of patients undergoing electroconvulsive therapy.
Description:
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Synonyms:
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Remifentanil is a mu-opioid agonist with rapid onset and peak effect, and short duration of action.
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About Remifentanil HCl
Remifentanil API was developed at Minakem’s Belgium facility in Louvain-la-Neuve more than 10 years ago.
Remifentanil API CAS number is 132875-61-7.
From a regulatory perspective, Minakem offers:
- A European DMF (CEP)
Therapeutical Class and Mechanism of Action
Remifentanil API is a synthetic opioid analgesic. It is classified as a short-acting opioid and is primarily used for pain management in anesthesia and intensive care settings.
Remifentanil API works by binding to opioid receptors, primarily the mu-opioid receptors in the central nervous system (CNS), particularly in the brain and spinal cord. The mechanism involves the following steps:
- Receptor Binding
- Inhibition of Pain Transmission
- Respiratory Depression and Sedation
- Short Duration of Action: Remifentanil has an extremely short half-life, making it ideal for rapid-onset analgesia and quick recovery.
Available forms
It is administered in the form remifentanil hydrochloride and in adults is given as an intravenous infusion in doses ranging from 0.1 microgram per kilogram per minute to 0.5 (μg/kg)/min. Children may require higher infusion rates (up to 1.0 (μg/kg)/min).[12] The clinically useful infusion rates are 0.025–0.1 (μg/kg)/min for sedation (rates adjusted to age of patient, severity of their illness and invasiveness of surgical procedure). Small amounts of other sedative medications are usually co-administered with remifentanil to produce sedation. Clinically useful infusion rates in general anesthesia vary but are usually 0.1–1 (μg/kg)/min.[13]
Pharmacology
Pharmacokinetics
Remifentanil is considered a metabolic soft drug,[14] one that is rapidly metabolized to an inactive form. Unlike other synthetic opioids which are hepatically metabolized, remifentanil has an ester linkage which undergoes rapid hydrolysis by non-specific tissue and plasma esterases. This means that accumulation does not occur with remifentanil and its context-sensitive half-life remains at 4 minutes after a 4-hour infusion
CAS 132875-61-7: Remifentanil
REMIFENTANIL | 132875-61-7
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