Buy Phenethylamine Cas 64-04-0

Buy Phenethylamine Cas 64-04-0

 

Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amine-associated receptor 1 (TAAR1) and inhibiting vesicular monoamine transporter 2 (VMAT2) in monoamine neurons.^[1][11][12] To a lesser extent, it also acts as a neurotransmitter in the human central nervous system.^[13] In mammals, phenethylamine is produced from the amino acid L-phenylalanine by the enzyme aromatic L-amino acid decarboxylase via enzymatic decarboxylation.^[14] In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, especially after microbial fermentation.

Phenethylamine is sold as a dietary supplement for purported mood and weight loss-related therapeutic benefits; however, in orally ingested phenethylamine, a significant amount is metabolized in the small intestine by monoamine oxidase B (MAO-B) and then aldehyde dehydrogenase (ALDH), which converts it to phenylacetic acid.^[5] This means that for significant concentrations to reach the brain, the dosage must be higher than for other methods of administration.^[5][6][15] Some authors have postulated that phenethylamine plays a role in affection without substantiating these claims with any direct evidence.^[16][17]

Phenethylamines, or more properly, substituted phenethylamines, are the group of phenethylamine derivatives that contain phenethylamine as a “backbone”; in other words, this chemical class includes derivative compounds that are formed by replacing one or more hydrogen atoms in the phenethylamine core structure with substituents. The class of substituted phenethylamines includes all substituted amphetamines, and substituted methylenedioxyphenethylamines (MDxx), and contains many drugs which act as empathogens, stimulants, psychedelics, anorectics, bronchodilators, decongestants, and/or antidepressants, among others. Buy Phenethylamine Cas 64-04-0

Phenethylamine is produced by a wide range of species throughout the plant and animal kingdoms, including humans;^[14][18] it is also produced by certain fungi and bacteria (genera: Lactobacillus, Clostridium, Pseudomonas and the family Enterobacteriaceae) and acts as a potent antimicrobial against certain pathogenic strains of Escherichia coli (e.g., the O157:H7 strain) at sufficient concentrations.^[19]

Phenethylamine is a primary amine, the amino-group being attached to a benzene ring through a two-carbon, or ethyl group.^[10] It is a colourless liquid at room temperature that has a fishy odor, and is soluble in water, ethanol and ether.^[10] Its density is 0.964 g/ml and its boiling point is 195 °C.^[10] Upon exposure to air, it combines with carbon dioxide to form a solid carbonate salt.^[20] Phenethylamine is strongly basic, pK_b = 4.17 (or pK_a = 9.83), as measured using the HCl salt, and forms a stable crystalline hydrochloride salt with a melting point of 217 °C.^[10][21] Its experimental log P is 1.41.^[10]

Substituted phenethylamines are a chemical class of organic compounds based upon the phenethylamine structure;^{[note 2]} the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents.

Many substituted phenethylamines are psychoactive drugs, which belong to a variety of different drug classes, including central nervous system stimulants (e.g., amphetamine), hallucinogens (e.g., 2,5-dimethoxy-4-methylamphetamine), entactogens (e.g., 3,4-methylenedioxyamphetamine), appetite suppressants (e.g. phentermine), nasal decongestants and bronchodilators (e.g., pseudoephedrine), antidepressants (e.g. bupropion), antiparkinson agents (e.g., selegiline), and vasopressors (e.g., ephedrine), among others. Many of these psychoactive compounds exert their pharmacological effects primarily by modulating monoamine neurotransmitter systems; however, there is no mechanism of action or biological target that is common to all members of this subclass. Buy Phenethylamine Cas 64-04-0

Numerous endogenous compounds—including hormones, monoamine neurotransmitters, and many trace amines (e.g., dopamine, norepinephrine, adrenaline, tyramine, and others)—are substituted phenethylamines. Dopamine is simply phenethylamine with a hydroxyl group attached to the 3 and 4 position of the benzene ring. Several notable recreational drugs, such as MDMA (ecstasy), methamphetamine, and cathinones, are also members of the class. All of the substituted amphetamines are phenethylamines, as well.

Pharmaceutical drugs that are substituted phenethylamines include phenelzine, phenformin, and fanetizole, among many others.

The N–methylated derivative of phenethylamine is N-methylphenethylamine.

Phenethylamine

For research use only. Not for therapeutic Use.

 

• CAT Number: R023775
• CAS Number: 64-04-0
• Molecular Formula: C8H11N
• Molecular Weight: 121.18
• Purity: ≥95%

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Phenethylamine（Cat No.:R023775）is an organic compound that functions as a natural monoamine alkaloid and neurotransmitter in the human brain. It plays a crucial role in enhancing mood, focus, and energy levels by stimulating the release of dopamine and norepinephrine. Due to its psychoactive properties, Phenethylamine is widely used in dietary supplements and studied for its potential therapeutic benefits in treating depression and attention-deficit disorders. Its high purity and consistency are vital for research and development in pharmaceuticals and neurochemical studies, contributing to advancements in mental health treatments. Buy Phenethylamine Cas 64-04-0

CAS Number	64-04-0
Synonyms	Benzeneethanamine; (2-Aminoethyl)benzene; (β-Aminoethyl)benzene; 1-Amino-2-phenylethane; 2-Amino-1-phenylethane; 2-Phenethylamine; 2-Phenyl-1-ethylamine; 2-Phenylethanamine; 2-Phenylethaneamine; 2-Phenylethylamine; Ethanamine, 2-phenyl-; N-(2-Phenyle
Molecular Formula	C8H11N
Purity	≥95%
Storage	Store at RT
IUPAC Name	2-phenylethanamine
InChI	InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2
InChIKey	BHHGXPLMPWCGHP-UHFFFAOYSA-N
SMILES	C1=CC=C(C=C1)CCN
Chemistry Calculators	Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator

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   • Physical State (20 deg.C): Liquid

   • Molecular Formula / Molecular Weight: C8H11N = 121.18
   • Product Number: P0085
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   • Boiling point: 197-200 °C (lit.)
   • Melting point: 60 °C

   • Density: 0.962 g/mL at 20 °C (lit.)
   • vapor density: 4.18 (vs air)
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   • CAS number: 64-04-0
   • EC number: 200-574-4

   • Catalogue Number: 807334
   • Synonyms: Phenethylamine
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   • CAS: 64-04-0
   • Molecular Formula: C8H11N

   • MDL Number: MFCD00008184
   • Molecular Weight (g/mol): 121.18
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   • CAS Number: 64-04-0
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    CAS Number: 64-04-0 Phenethylamine is a psychoactive drug and stimulant that affects dopamine levels. It uses a mechanism of inverse agonism at the D2 dopamine receptor to achieve this effect.