Buy Lysergic acid Cas 82-58-6
Lysergic acid, also known as D-lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of Argyreia nervosa (Hawaiian baby woodrose), and Ipomoea species (morning glories, ololiuhqui, tlitliltzin).
Amides of lysergic acid, lysergamides, are widely used as pharmaceuticals and as psychedelic drugs, e.g. lysergic acid diethylamide (LSD). Lysergic acid is listed as a Table I precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.[3]
The name “lysergic acid” comes from the fact that it is a carboxylic acid, and it was first made by hydrolysis of various ergot alkaloids.[4]
Pharmacology
Lysergic acid failed to produce LSD-like electroencephalogram (EEG) changes in rabbits.[5]
Chemistry
Synthesis
Laboratory
Lysergic acid is generally produced by hydrolysis[6] of natural lysergamides, but can also be synthesized in the laboratory by a complex total synthesis, for example by Robert Burns Woodward‘s team in 1956.[7] An enantioselective total synthesis based on a palladium-catalyzed domino cyclization reaction has been described in 2011 by Fujii and Ohno.[8] Lysergic acid monohydrate crystallizes in very thin hexagonal leaflets when recrystallized from water. Lysergic acid monohydrate, when dried (140 °C at 2 mmHg or 270 Pa) forms anhydrous lysergic acid.
Biosynthesis
The biosynthetic route is based on the alkylation of the amino acid tryptophan with dimethylallyl diphosphate (isoprene derived from 3R–mevalonic acid) giving 4-dimethylallyl-L-tryptophan which is N-methylated with S-adenosyl-L-methionine. Oxidative ring closure followed by decarboxylation, reduction, cyclization, oxidation, and allylic isomerization yields D-(+)-lysergic acid.[4] The biosynthetic pathway has been reconsituted in transgenic baker’s yeast. Buy Lysergic acid Cas 82-58-6
Isomers
Lysergic acid is a chiral compound with two stereocenters. The isomer with inverted configuration at carbon atom 8 close to the carboxyl group is called isolysergic acid. Inversion at carbon 5 close to the nitrogen atom leads to L-lysergic acid and L-isolysergic acid, respectively
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Introduction to Lysergic Acid
Lysergic acid CAS 82-58-6 is a naturally occurring compound that belongs to the ergoline family of alkaloids. It serves as a fundamental building block and precursor for the synthesis of various lysergamides, including the well-known and highly potent psychedelic substance known as LSD (lysergic acid diethylamide). Discovered and isolated by Swiss chemist Albert Hofmann in 1938, lysergic acid has since garnered significant attention and intrigue in the fields of chemistry, pharmacology, and psychopharmacology.
Lysergic acid derives its name from the fungus Claviceps purpurea, commonly known as ergot, which grows on various grains, particularly rye. This fungus naturally produces a group of alkaloids called ergot alkaloids, and lysergic acid is one of them. Lysergic acid acts as a central component in the biosynthesis of these ergot alkaloids, which possess a range of biological activities.
While lysergic acid itself does not exhibit significant psychoactive effects, its derivative LSD has gained notoriety for its powerful hallucinogenic properties.
Chemical and Physical Properties of Lysergic Acid
Lysergic acid CAS 82-58-6, with its unique chemical structure, possesses distinct chemical and physical properties that contribute to its intriguing characteristics. It is a crystalline solid that appears as colorless leaf shaped crystals. The molecular formula of lysergic acid is C16H16N2O2, with a molecular weight 268.32 g/mole.
Lysergic acid is sparingly soluble in water, meaning it dissolves only to a limited extent; slightly soluble in benzene, ether. However, it exhibits good solubility in organic solvents such as ethanol, methanol, chloroform, pyridine and dimethyl sulfoxide (DMSO). These solvents are commonly used for the extraction and purification of lysergic acid.
The compound has a melting point ranging from 238 to 240 °C (460 to 464 °F), indicating its solid state at room temperature. However, it is crucial to note that lysergic acid is sensitive to light, heat, and air. Easily oxidized during storage. Exposure to these factors can lead to degradation. Therefore, proper storage and handling in a cool, dark, and airtight environment are necessary to maintain its stability and integrity.
Uses of Lysergic Acid
Lysergic acid, despite lacking significant psychoactive effects itself, plays a crucial role in various applications and research endeavors. Its primary use lies in serving as a precursor for the synthesis of LSD (lysergic acid diethylamide), a powerful psychedelic substance. However, lysergic acid also finds application in other areas, both within and beyond the realm of recreational drug use.
Synthesis of LSD
Lysergic acid serves as the key starting material in the synthesis of LSD. Through a chemical processes, lysergic acid is turned into LSD. LSD, known for its profound hallucinogenic effects, has been the subject of extensive research and exploration, particularly in the realms of neuroscience, psychology, and consciousness studies.
Research and Psychopharmacology
Lysergic acid and its derivatives, including LSD, have garnered significant attention in the scientific community. Researchers have conducted studies to better understand the pharmacological effects, mechanisms of action, and potential therapeutic applications of these compounds. Studies involving lysergic acid and LSD have explored areas such as consciousness alteration, psychotherapy, creativity enhancement, and the treatment of psychiatric disorders, including depression, anxiety, and addiction.
Drug Discovery
Lysergic acid and its analogs have been investigated as potential starting points for the development of new medications. Researchers have explored their interactions with various receptors in the brain, aiming to harness their therapeutic potential. These efforts have yielded insights into the serotonin system and have contributed to advancements in drug discovery and the understanding of receptor binding.
Analytical Reference Standard
Lysergic acid is also utilized as an analytical reference standard in laboratory settings. It serves as a benchmark compound for identifying and quantifying lysergic acid derivatives, including LSD, in analytical techniques such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS). The availability of lysergic acid as a reference standard facilitates accurate and reliable analysis in forensic and research applications.
While the recreational use of lysergic acid and LSD remains controversial and subject to legal restrictions in many jurisdictions, scientific interest in their potential benefits continues to grow. Ongoing research seeks to unravel the mechanisms of action, therapeutic potential, and possible risks associated with lysergic acid and its derivatives.
Manufacturing of Lysergic Acid
The manufacturing process of lysergic acid involves several steps, starting from the natural source of the compound, the ergot fungus (Claviceps purpurea). This fungus commonly grows on various grains, particularly rye, and contains ergot alkaloids, including lysergic acid, as natural components.
Cultivation and Harvesting: The first step in manufacturing lysergic acid involves the cultivation and harvesting of ergot fungus. Cultivation typically takes place in controlled environments, where the fungus is grown on a substrate such as sterilized rye grain. This process ensures the optimal growth and development of ergot, allowing for a higher yield of lysergic acid.
Extraction: Once the ergot fungus has matured, it is harvested and subjected to extraction processes to isolate the ergot alkaloids, including lysergic acid. Extraction techniques often involve the use of solvents such as ethanol, methanol, or chloroform. These solvents help dissolve and extract the desired alkaloids from the fungal material, forming a crude extract.
Purification and Isolation: Following extraction, the crude extract undergoes purification steps to isolate lysergic acid. The purification process typically involves various separation techniques such as filtration, chromatography, and crystallization. These methods help separate lysergic acid from other impurities present in the crude extract, resulting in a purified form of the compound.
Chemical Modification: Once lysergic acid has been isolated, it can undergo chemical modifications for specific applications. The most notable application is the synthesis of LSD (lysergic acid diethylamide). Through a chemical process called an amidation reaction, lysergic acid reacts with diethylamine, resulting in the formation of LSD. This reaction typically takes place under controlled laboratory conditions and requires expertise in organic chemistry.
Formulation and Packaging: Depending on the intended use, lysergic acid can be further processed and formulated into various forms such as tablets, capsules, or liquid solutions. These formulations allow for convenient administration and dosing in research or medical settings.
Chemical syntheis
Lysergic acid can be obtained by the hydrolysis of organic lysergamides, although it can be synthetically produced in a lab using a detailed total synthesis, for instance, by using a method developed by Robert Burns Woodward’s group in 1956. In 2011, Fujii and Ohno proposed an enantioselective total synthesis dependent on a domino cyclization reaction catalyzed by palladium. When recrystallized from water, lysergic acid monohydrate crystallizes as very thin hexagonal plates. When dried at 140 °C and a pressure of 2 mmHg (or 270 Pa), lysergic acid is transformed into anhydrous lysergic acid. The manufacturing procedure begins by alkylating the amino acid tryptophan with dimethylallyl diphosphate (which is derived from 3R-mevalonic acid) to form 4-dimethylallyl-L-tryptophan, which is subsequently N-methylated employing S-adenosyl-L-methionine. After oxidative ring closure, decarboxylation, reduction, cyclization, oxidation, and allylic isomerization, D-(+)-lysergic acid is produced.
Lysergic Acid Legal Status
Lysergic acid and its derivatives, including LSD, have a complex and highly regulated legal status in many countries worldwide. Due to the psychoactive properties and potential for misuse, lysergic acid and LSD are classified as controlled substances in numerous jurisdictions. The production, possession, distribution, and use of these substances outside of authorized research or medical contexts are generally illegal. The legal status of lysergic acid varies from country to country, with some nations strictly prohibiting all forms of its use, while others may allow limited research or therapeutic applications under strict regulations. It is essential to be aware of and comply with the legal requirements and restrictions regarding lysergic acid in each respective jurisdiction to avoid legal consequences. Additionally, regulations surrounding lysergic acid are subject to change, so it is crucial to stay updated on current legislation and regulations related to these substances.
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1P-LSD or 1-propionyl-lysergic acid diethylamide is a psychedelic drug of the lysergamide class that is a derivative and functional analogue of LSD and a homologue of ALD-52.
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1P-LSD or 1-Propionyl-LSD in the form of blotters is a new designer drug that replaces LSD and has all of its properties. 1P-LSD is reminiscent of the MLD-41 and ALD-52 indole prodrug.
1-Propionyl-d-lysergic acid diethylamide (also known as 1P-LSD) is a novel semi-synthetic psychedelic substance of the lysergamide class. 1P-LSD is closely related to LSD and is reported to produce near-identical effects. Little is known about the pharmacology of 1P-LSD, but it likely produces its psychedelic effects by acting on serotonin receptors in the brain.
Product Details:
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Product Name: 1P-LSD Powder
IUPAC: (6aR,9R)-N,N-diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
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1P-LSD Powder ,1-Propionyl-d-lysergic acid diethylamide (also known as 1P-LSD) is a novel semi-synthetic psychedelic substance of the lysergamide class that produces LSD-like psychedelic effects when administered. It is structurally related to psychedelic lysergamides like LSD and ALD-52.
Like ALD-52, it is theorized to act as a prodrug for LSD.The structural resemblance 1P-LSD shares with LSD predicts an extremely similar effect profile, with perhaps the only significant differences stemming from variations in the rate of absorption, duration, metabolism, and excretion of the compound (i.e. its pharmacokinetic factors).
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Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-LSD Powder, and it has a very brief history of human usage. In the first few months of 2015, 1P-LSD began to be marketed as a legal alternative to LSD alongside lysergamides like ALD-52, ETH-LAD and AL-LAD and sold online as a research chemical.
As with LSD itself, 1P-LSD Powder does not meet the criteria to be considered addictive or toxic by the scientific community. Nevertheless, unpredictable adverse reactions such as anxiety, paranoia, delusions and psychosis are always liable to occur, particularly among those who are predisposed to mental disorders. While these negative reactions or “bad trips” can often be attributed to factors like the user inexperience or improper preparation of set and setting, they have been known to happen among even highly experienced users as well. It is highly advised to approach this very potent, long-lasting hallucinogenic substance with the proper amount of preparation, and harm reduction practices if using it
it is a molecule of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH3CH2CO- bound to an amino group. 1P-LSD Powder is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.
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