Buy Benzylamine phenylmethylamine Cas 100-46-9
Buy Benzylamine phenylmethylamine Cas 100-46-9
Benzylamine, also known as phenylmethylamine, is an organic chemical compound with the condensed structural formula C6H5CH2NH2 (sometimes abbreviated as PhCH2NH2 or BnNH2). It consists of a benzyl group, C6H5CH2, attached to an amine functional group, NH2. This colorless water-soluble liquid is a common precursor in organic chemistry and used in the industrial production of many pharmaceuticals. The hydrochloride salt was used to treat motion sickness on the Mercury-Atlas 6 mission in which NASA astronaut John Glenn became the first American to orbit the Earth.[4]
Manufacturing
Benzylamine can be produced by several methods, the main industrial route being the reaction of benzyl chloride and ammonia. It is also produced by the reduction of benzonitrile and reductive amination of benzaldehyde, both done over Raney nickel.[5]
It was first produced accidentally by Rudolf Leuckart in the reaction of benzaldehyde with formamide in a process now known as the Leuckart reaction.[6]
Biochemistry
Benzylamine occurs biologically from the action of the N-substituted formamide deformylase enzyme, which is produced by Arthrobacter pascens bacteria.[7] This hydrolase catalyses the conversion of N-benzylformamide into benzylamine with formate as a by-product.[8] Benzylamine is degraded biologically by the action of the monoamine oxidase B enzyme,[9] resulting in benzaldehyde. Buy Benzylamine phenylmethylamine Cas 100-46-9
Uses
Benzylamine is used as a masked source of ammonia, since after N–alkylation, the benzyl group can be removed by hydrogenolysis:[11]
- C6H5CH2NH2 + 2 RBr → C6H5CH2NR2 + 2 HBr
- C6H5CH2NR2 + H2 → C6H5CH3 + R2NH
Typically a base is employed in the first step to absorb the HBr (or related acid for other kinds of alkylating agents).
Benzylamine reacts with acetyl chloride to form N-benzylacetamide.
Isoquinolines can be prepared from benzylamine and glyoxal acetal by an analogous approach known as the Schlittler-Müller modification to the Pomeranz–Fritsch reaction. This modification can also be used for preparing substituted isoquinolines
100-46-9
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Basic information
- Product Name: Benzylamine
- Synonyms: Moringine;moringine[qr];omega-Aminotoluene;omega-aminotoluene[qr];Sumine 2005;sumine2005;sumine2006;BZA
- CAS NO:100-46-9
- Molecular Formula: C7H9N
- Molecular Weight: 107.15306
- EINECS: 202-854-1
- Product Categories: Pharmaceutical Intermediates;Organics
- Mol File: 100-46-9.mol
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Chemical Properties
- Melting Point: -30 °C
- Boiling Point: 184-185 °C(lit.)
- Flash Point: 140 °F
- Appearance: Clear colorless to slightly yellow/Liquid
- Density: 0.981 g/mL at 25 °C(lit.)
- Vapor Pressure: 0.713mmHg at 25°C
- Refractive Index: n20/D 1.543(lit.)
- Storage Temp.: room temp
- Solubility: alcohol: miscible
- PKA: 9.33(at 25℃)
- Explosive Limit: 0.7-8.2%(V)
- Water Solubility: soluble
- Sensitive: Air Sensitive
- Stability: Stability Combustible. Incompatible with strong oxidizing agents, strong acids.
- Merck: 14,1125
- BRN: 741984
- CAS DataBase Reference: Benzylamine(CAS DataBase Reference)
- NIST Chemistry Reference: Benzylamine(100-46-9)
- EPA Substance Registry System: Benzylamine(100-46-9)
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Safety Data
- Hazard Codes: C
- Statements: 21/22-34
- Safety Statements: 26-36/37/39-45
- RIDADR: UN 2735 8/PG 2
- WGK Germany: 1
- RTECS: DP1488500
- F: 34
- TSCA: Yes
- HazardClass: 8
- PackingGroup: II
- Hazardous Substances Data: 100-46-9(Hazardous Substances Data)
100-46-9 Suppliers
Benzylamine is an organic compound containing an amine group and a benzene ring.
Check Digit Verification of cas no
The CAS Registry Mumber 100-46-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 0 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 100-46:
(5*1)+(4*0)+(3*0)+(2*4)+(1*6)=19
19 % 10 = 9
So 100-46-9 is a valid CAS Registry Number.
100-46-9 Well-known Company Product Price
- Brand
- (Code)Product description
- CAS number
- Packaging
- Price
- Detail
- TCI America
- (B0406) Benzylamine >99.0%(GC)
- 100-46-9
- 25mL
- 80.00CNY
- Detail
- TCI America
- (B0406) Benzylamine >99.0%(GC)
- 100-46-9
- 500mL
- 190.00CNY
- Detail
- Alfa Aesar
- (A10997) Benzylamine, 98+%
- 100-46-9
- 250g
- 224.0CNY
- Detail
- Alfa Aesar
- (A10997) Benzylamine, 98+%
- 100-46-9
- 500g
- 331.0CNY
- Detail
- Alfa Aesar
- (A10997) Benzylamine, 98+%
- 100-46-9
- 1000g
- 632.0CNY
- Detail
- Alfa Aesar
- (A10997) Benzylamine, 98+%
- 100-46-9
- 5000g
- 2735.0CNY
- Detail
- Sigma-Aldrich
- (13180) Benzylamine for GC derivatization, ≥99.0%
- 100-46-9
- 13180-10X1ML
- 957.06CNY
- Detail
- Sigma-Aldrich
- (13180) Benzylamine for GC derivatization, ≥99.0%
- 100-46-9
- 13180-100ML
- 304.20CNY
- Detail
- Sigma-Aldrich
- (13180) Benzylamine for GC derivatization, ≥99.0%
- 100-46-9
- 13180-500ML
- 786.24CNY
- Detail
100-46-9SDS
SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) – Sixth revised edition
Version: 1.0
Creation Date: Aug 10, 2017
Revision Date: Aug 10, 2017
1.Identification
1.1 GHS Product identifier
| Product name | Benzylamine |
|---|
1.2 Other means of identification
| Product number | – |
|---|---|
| Other names | Phenylmethanamine |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier’s details
1.5 Emergency phone number
| Emergency phone number | – |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
More Details:100-46-9 SDS
100-46-9Synthetic route
- 104669-74-1benzyl carbamic acid allyl ester
- 100-46-9benzylamine
- 42116-44-9N-tert-butoxycarbonylbenzylamine
- 100-46-9benzylamine
- 52826-45-6(benzylimino)triphenylphosphorane
- 100-46-9benzylamine
- 383865-57-44-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine
-
A
- 1-Benzyl-3-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-urea
-
B
- 100-46-9benzylamine
- 122954-29-4benzylammonium O-ethylstyrylphosphonate
-
A
- 5849-49-0styrylphosphonic acid ethylester
-
B
- 100-46-9benzylamine
- 54535-21-62-(benzylamino-methylene)-malonic acid diethyl ester
- 100-46-9benzylamine
- N-benzyl-3,3-dimethoxypropylsulfonamide
- 100-46-9benzylamine
- 1-naphthylmethyl N-benzyl carbamate
- 100-46-9benzylamine
- 119592-74-4N-benzyl-2,2,6,6-tetramethyl-2,6-disilapiperidine
- 100-46-9benzylamine
- 286-20-4cyclohexane-1,2-epoxide
- 100-46-9benzylamine
- 40571-86-6, 40571-87-7, 51925-39-4, 131164-07-3, 141553-09-5rac-(1R,2R)-2-(benzylamino)cyclohexanol
- 104-88-14-chlorobenzaldehyde
- 100-46-9benzylamine
- 130517-96-3, 13540-93-7N-(4-chlorobenzylidene)benzylamine
- 292638-85-8acrylic acid methyl ester
- 100-46-9benzylamine
- 23574-01-83-benzylamino-propionic acid methyl ester
- 292638-85-8acrylic acid methyl ester
- 100-46-9benzylamine
- 793-19-1bis(2-methoxycarbonylethyl)benzylamine
- 54221-37-3diethyl meso-2,5-dibromoadipate
- 100-46-9benzylamine
- 17740-40-8diethyl meso-1-benzyl-2,5-pyrrolidinedicarboxylate
100-46-9Upstream product
- 103-82-2phenylacetic acid
- 622-79-7benzyl azide
- 2142-01-0N-benzylphthalimide
- 100-97-0hexamethylenetetramine
- 100-44-7benzyl chloride
- 538-32-9benzylurea
- 1576-37-0N-benzyl-p-toluenesulfonamide
- 81467-37-01-acetyl-3-benzylthiourea
- 5327-45-7N-benzyl-octadecanamide
- 60-29-7diethyl ether
- 144-62-7oxalic acid
- 60-35-5acetamide
- 100-39-0benzyl bromide
- 100-52-7benzaldehyde
100-46-9Downstream Products
- 101-32-6N-benzyl-diethanolamine
- 104-63-2N-Benzylethanolamine
- 29897-82-3N-benzylpyrrolidine
- 2547-66-21,3,5-Tribenzyl-1,3,5-triazacyclohexane
- 2182-52-7benzylamine acetic acid
- 109339-13-13-benzyl-3a-methyl-hexahydro-furo[2,3-d]thiazole
- 2937-99-7N-benzyl-5-aminopentan-1-ol
- 6312-25-0N?[2?(2?pyridyl)ethyl]phenethylamine
- 31582-29-3(N-benzyl)-bis-[2-(pyrid-2-yl)ethyl]amine
- 110435-77-3benzyl-bis-(2-[4]pyridyl-ethyl)-amine
- 183275-87-8N-benzyl-1-(tetrahydrofuran-2-yl)methanamine
- 4393-11-7N-benzyl-1-(furan-2-yl)methanimine
- 4439-53-6N-benzyl(furan-2-ylmethyl)amine
- 13556-71-3N-benzyl-4-aminopyridine
100-46-9Related news
Hematite nanostructures: An old material for a new story. Simultaneous photoelectrochemical oxidation of Benzylamine (cas 100-46-9) and hydrogen production through Ti doping07/19/2019Overall water splitting represents one of the most promising approaches toward solar energy conversion and storage, which is, however, severely challenged by the four-electron/four-proton nature of the oxygen evolution reaction (OER). One option to overcome this issue is to replace OER with a mo…detailed
100-46-9Relevant academic research and scientific papers
Preparation and characterization of primary amines by potassium borohydride-copper chloride system from nitriles
Jiang, Han,Hu, Jialei,Xu, Xinliang,Zhou, Yifeng
, p. 3564 – 3566 (2015)
Nitriles undergo reduction to primary amines under optimized conditions at 50 °C using 0.25 equiv of copper chloride and 3.0 equiv of potassium borohydride in 80 % isopropanol. The aromatic and aralkyl nitriles could be effectively reduced in yield ranging from 60 to 90 %.
Catalytic transamidation under moderate conditions
Eldred, Sarah E.,Stone, David A.,Gellman, Samuel H.,Stahl, Shannon S.
, p. 3422 – 3423 (2003)
The carboxamide group is generally inert, except under harsh conditions or in the presence of highly evolved enzymes. We have identified several metal complexes that efficiently catalyze transamidation reactions of amide/amine mixtures under moderate cond
Electronic Effect of Ruthenium Nanoparticles on Efficient Reductive Amination of Carbonyl Compounds
Komanoya, Tasuku,Kinemura, Takashi,Kita, Yusuke,Kamata, Keigo,Hara, Michikazu
, p. 11493 – 11499 (2017)
Highly selective synthesis of primary amines over heterogeneous catalysts is still a challenge for the chemical industry. Ruthenium nanoparticles supported on Nb2O5 act as a highly selective and reusable heterogeneous catalyst for the low-temperature reductive amination of various carbonyl compounds that contain reduction-sensitive functional groups such as heterocycles and halogens with NH3 and H2 and prevent the formation of secondary amines and undesired hydrogenated byproducts. The selective catalysis of these materials is likely attributable to the weak electron-donating capability of Ru particles on the Nb2O5 surface. The combination of this catalyst and homogeneous Ru systems was used to synthesize 2,5-bis(aminomethyl)furan, a monomer for aramid production, from 5-(hydroxymethyl)furfural without a complex mixture of imine byproducts.
A Mild and Base-Free Protocol for the Ruthenium-Catalyzed Hydrogenation of Aliphatic and Aromatic Nitriles with Tridentate Phosphine Ligands
Adam, Rosa,Bheeter, Charles Beromeo,Jackstell, Ralf,Beller, Matthias
, p. 1329 – 1334 (2016)
A novel protocol for the general hydrogenation of nitriles in the absence of basic additives is described. The system is based on the combination of [Ru(cod)(methylallyl)2] (cod=cyclooctadiene) and L2. A variety of aromatic and aliphatic nitriles is hydrogenated under mild conditions (50 °C and 15 bar H2) with this system. Kinetic studies revealed higher activity in the case of aromatic nitriles compared with aliphatic ones.
β-TRIMETHYLSILYLETHANESULFONYL CHLORIDE (SES-Cl): A NEW REAGENT FOR PROTECTION OF AMINES
Weinreb, Steven M.,Demko, Donald M.,Lessen, Thomas A.,Demers, James P.
, p. 2099 – 2102 (1986)
The title compound, easily prepared in two steps from vinyltrimethylsilane, is a useful reagent for the protection of primary and secondary amines as their sulfonamides, which are cleaved by fluoride ion.
Benzylamine Cas 100-46-9
Product Nam: Benzylamine
CAS No: 100-46-9
Molecular Formula: C7H9N
Molecular Weight: 107.15306
Appearance: Colorless transparent liquid
Assay: 99.0%min
Description
Benzylamine Quick Details
Product Nam: Benzylamine
Synonyms: alpha-Aminotoluene; Benzenemethanamine; Phenylmethylamine
CAS No: 100-46-9
Molecular Formula: C7H9N
Molecular Weight: 107.15306
Appearance: Colorless transparent liquid
Assay: 99.0%min
Benzylamine Typical Properties
| Test Items | Specification | Results |
| Appearance | Colorless transparent liquid | Colorless transparent liquid |
| Content | ≥99.00% | 99.88% |
| Water | ≤0.30% | 0.09% |
Benzylamine Usage
1. Benzylamine is an intermediate for the preparation of the insecticides imidacloprid and acetamiprid, and is also an intermediate of the pharmaceutical sulfametholone.
2. Used as an analytical reagent.
3. Used as dyes and pharmaceutical intermediates
4. A precipitant for the determination of molybdate, vanadate, tungstate, titanium, cobalt, osmium, iridium and osmium for use in microcrystallization analysis. Used as an intermediate in dyes, pharmaceuticals and polymers.
5. Organic synthesis intermediates. For example, benzylamine is acetylated to give Acetylbenzylamine.
6. Benzylamine is an important organic synthesis intermediate. Mainly used in the pharmaceutical industry for the synthesis of Homosulfamin and Sulfamilamide (Napaltan)
7. A precipitant for the determination of molybdate, vanadate, tungstate, cerium, zirconium, hafnium, tantalum, niobium and tantalum in microscopic crystal analysis. Organic analysis is used to distinguish between various types of carboxylic acids (reacting with carboxylic acid esters to form N-benzylamine derivatives, distinguishing various carboxylic acids by melting point), and qualitative tests of organometallic compounds.
BenzylaminePackage
200kg/drum or According to customer requirements.
BenzylamineStorage
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