Buy Dextromethamphetamine Cas 51-64-9

Buy Dextromethamphetamine Cas 51-64-9

Cas 51-64-9

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Buy Dextromethamphetamine Cas 51-64-9

Buy Dextromethamphetamine Cas 51-64-9

Dextroamphetamine is a central nervous system (CNS) stimulant and enantiomer of amphetamine that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.[6][22] It is also used illicitly to enhance cognitive and athletic performance, and recreationally as an aphrodisiac and euphoriant. Dextroamphetamine is generally regarded as the prototypical stimulant.

The amphetamine molecule exists as two enantiomers, levoamphetamine and dextroamphetamine. Dextroamphetamine is the dextrorotatory, or ‘right-handed’, enantiomer and exhibits more pronounced effects on the central nervous system than levoamphetamine. Pharmaceutical dextroamphetamine sulfate is available as both a brand name and generic drug in a variety of dosage forms. Dextroamphetamine is sometimes prescribed as the inactive prodrug lisdexamfetamine.

Side effects of dextroamphetamine at therapeutic doses include elevated mood, decreased appetite, dry mouth, excessive grinding of the teeth, headache, increased heart rate, increased wakefulness or insomnia, anxiety, and irritability, among others.[23] At excessive doses, psychosis (i.e., hallucinations, delusions), addiction, and rapid muscle breakdown may occur. However, for individuals with pre-existing psychotic disorders, there may be a risk of psychosis even at therapeutic doses.[24]

Dextroamphetamine, like other amphetamines, elicits its stimulating effects via several distinct actions: it inhibits or reverses the transporter proteins for the monoamine neurotransmitters (namely the serotonin, norepinephrine and dopamine transporters) either via trace amine-associated receptor 1 (TAAR1) or in a TAAR1 independent fashion when there are high cytosolic concentrations of the monoamine neurotransmitters[25] and it releases these neurotransmitters from synaptic vesicles via vesicular monoamine transporter 2 (VMAT2).[26] It also shares many chemical and pharmacological properties with human trace amines, particularly phenethylamine and N-methylphenethylamine, the latter being an isomer of amphetamine produced within the human body. It is available as a generic medication.[23] In 2022, mixed amphetamine salts (Adderall) was the 14th most commonly prescribed medication in the United States, with more than 34 million prescriptions. Buy Dextromethamphetamine Cas 51-64-9

Uses

Medical

Dexedrine Spansule 5, 10, and 15 mg capsules, a sustained-release dosage form of dextroamphetamine

Dextroamphetamine is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy,[6] and is sometimes prescribed off-label for depression and obesity.[22]

ADHD

Long-term amphetamine exposure at sufficiently high doses in some animal species is known to produce abnormal dopamine system development or nerve damage,[29][30] but, in humans with ADHD, long-term use of pharmaceutical amphetamines at therapeutic doses appears to improve brain development and nerve growth.[31][32][33] Reviews of magnetic resonance imaging (MRI) studies suggest that long-term treatment with amphetamine decreases abnormalities in brain structure and function found in subjects with ADHD, and improves function in several parts of the brain, such as the right caudate nucleus of the basal ganglia

Buy Dextromethamphetamine Cas 51-64-9

Basic Information
CAS No.: 51-64-9
Name: D-AMPHETAMINE HYDROCHLORIDE
Molecular Structure:
Molecular Structure of 51-64-9 (D-AMPHETAMINE HYDROCHLORIDE)
Formula: C9H13 N
Molecular Weight: 135.209
Synonyms: Benzeneethanamine,a-methyl-, (S)-;Phenethylamine, a-methyl-, (+)- (8CI);(+)-(S)-Amphetamine;(+)-Phenaminum;(+)-a-Methylphenethylamine;(2S)-(+)-Amphetamine;(S)-(+)-Amphetamine;(S)-(+)-b-Phenylisopropylamine;(S)-1-Methyl-2-phenylethylamine;(S)-1-Phenyl-2-aminopropane;(S)-1-Phenyl-2-propanamine;(S)-1-Phenyl-2-propylamine;(S)-Amphetamine;(S)-a-Methylphenethylamine;D-(+)-Amphetamine;D-Amphetamine;Dexadrine;Dexamfetamine;Dexamphetamine;Dextroamphetamine;Metamina;NSC 73713;d-(S)-Amphetamine;d-Amphetamine;(+)-Amphetamine;
EINECS: 200-112-1
Density: 0.946 g/cm3
Melting Point: 25°C
Boiling Point: 201.5 °C at 760 mmHg
Flash Point: 87.4 °C
Solubility: Slightly soluble in water.
Appearance: Colorless, oily liquid.
Hazard Symbols: F,T
Risk Codes: 11-23/24/25-39/23/24/25
Safety: Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Chronic exposure causes central nervous system damage and blood-pressure effects. When heated to decomposition it emits toxic NOx. See other amphetamine entries.
PSA: 26.02000
LogP: 3.07860
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Chemistry

The molecular formula of  d-Amphetamine(51-64-9) is C9H13N  and its molecular weight is 135.20.
Synonyms:(-)-alpha-Phenylpropylamine;(S)-(+)-beta-Phenylisopropylamine;alpha-Methylphenethylamine, d-form;alpha-methylphenethylamine,d-form;amphetamine(d);Amphetamine, (d);Benzeneethanamine, alpha-methyl-, (S)-;component of Amodex
Molecular Structure:

History

1、d-amphetamine was first synthesized under the chemical name “phenylisopropylamine” in Berlin, 1887 by the Romanian chemist Lazar Edeleanu. It was not widely marketed until 1932.
Three years later, in 1935, the medical community became aware of the stimulant properties of amphetamine.
2、In 1937 Smith, Kline, and French introduced tablets under the tradename Dexedrine.
3、It quickly became apparent that dextroamphetamine and other amphetamines had a high potential for misuse, although they were not heavily controlled until 1970.
4、Internationally, it has been available under the names AmfeDyn (Italy), Curban (US), Obetrol (Switzerland), Simpamina (Italy), Dexedrine (US), Dextropa (Portugal), and Stild (Spain).

Uses

d-Amphetamine(51-64-9) is used as CNS stimulant; anorexic. More active isomer of Amphetamine. Induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites; blocks catecholamine reuptake. Controlled substance (stimulant).

Toxicity Data With Reference

1.

scu-rat TDLo:25 mg/kg (female 5-9 D post):REP

 DABBBA    Dissertation Abstracts International, B: The Sciences and Engineering. 31 (1971),6304.
2.

orl-man TDLo:42 mg/kg/25 W-I

 BIPCBF    Biological Psychiatry. 20 (1985),1332.
3.

orl-cld TDLo:3600 µg/kg/10 D-I

 AJPSAO    American Journal of Psychiatry. 143 (1985),1176.
4.

orl-rat LD50:38 mg/kg

 TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
5.

ipr-rat LDLo:20 mg/kg

 AEPPAE    Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 195 (1940),647.
6.

scu-rat LD50:200 mg/kg

 27ZIAQ    Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,84.
7.

orl-mus LD50:40 mg/kg

 TXAPA9    Toxicology and Applied Pharmacology. 41 (1977),329.
8.

ipr-mus LD50:4400 µg/kg

 AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 161 (1966),206.
9.

scu-mus LD50:20 mg/kg

 AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 146 (1963),392.

Consensus Reports

d-Amphetamine(51-64-9) is reported in EPA TSCA Inventory.

Safety Profile

RIDADR：  3249
HazardClass：  6.1(a)
PackingGroup：  II
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Chronic exposure causes central nervous system damage and blood-pressure effects. When heated to decomposition it emits toxic NOx. See other amphetamine entries.

Specification

Contraindications
Do not use in patients with a history of drug abuse. Do not use during or within 14 days following the administration of MAO inhibitors; hypertensive crises may result. Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, glaucoma and agitated states. Amphetamines should not be used to combat fatigue or to replace rest.
Synonyms
Synonyms
  • (S)-α-Benzylethylamine
  • Dextroamphetamine
  • NSC 73713
Technical Information
Formal Name
α-methyl-benzeneethanamine
CAS Number
51-64-9
Molecular Formula
C9H13N
Formula Weight
135.2
Formulation
A 1 mg/ml solution in methanol
SMILES
N[C@@H](C)CC1=CC=CC=C1
InChi Code
InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1
InChi Key
KWTSXDURSIMDCE-QMMMGPOBSA-N
Regulatory Information
DEA Exempt Notification
This product is a DEA exempt preparation of a scheduled compound – does not require DEA Controlled Substance registration or DEA 222 form. For alternate sizes please contact sales.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 4 years
Structural Formula
Dextroamphetamine
CAS:
51-64-9
EINECS:
Molecular Formula:
C9H14ClN
MDL:
Synonym:
(2s)-(+)-amphetamine ; dexacaps ; (+)-(s)-amphetamine ; benzeneethanamine,a-methyl-, (s)- ; dexamfetamine ; c07884 ; (s)-1-phenyl-2-propanamine ; dexadrine ; nsc 73713 ; amphetamine(d) ; (s)-1-phenyl-2-propylamine ; dextroamphetamine ; (s)-amphetamine ; (s)-(+)-b-phenylisopropylamine ; benzeneethanamine, a-methyl-, (as)- ; (+)-amphetamine ; dexedrine ; metamina ; (s)-a-methylphenethylamine ; dexidrine ; (s)-1-methyl-2-phenylethylamine ; d-(+)-amphetamine ; (s)-1-phenyl-2-aminopropane ; (+)-phenaminum ; phenethylamine, a-methyl-, (+)- (8ci) ; dexamphetamine ; (s)-(+)-amphetamine ; d-(s)-amphetamine ; (+)-a-methylphenethylamine ; d-amphetamine ; nsc-73713

 

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    • Melting point: 25°C
    • Density: 0.9354 (estimate)
    • refractive index: 1.5087 (estimate)

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