Buy Etorphine (M99) powder
Etorphine (M99) is a semi-synthetic opioid possessing an analgesic potency approximately 1,000–3,000 times that of morphine.[1] It was first prepared in 1960 from oripavine, which does not generally occur in opium poppy extract but rather the related plants Papaver orientale and Papaver bracteatum.[2] It was reproduced in 1963 by a research group at MacFarlan Smith in Edinburgh, led by Kenneth Bentley.[3] It can be produced from thebaine.[4]
Veterinary use
Etorphine is available legally only for veterinary use and is strictly governed by law. It is often used to immobilise elephants and other large mammals. Diprenorphine (Revivon) is an opioid receptor antagonist that can be administered in proportion to the amount of etorphine used (1.3 times) to reverse its effects. Veterinary-strength etorphine is fatal to humans. For this reason the package as supplied to vets always includes the human antidote along with the etorphine. Buy Etorphine (M99) powder
The human antidote is generally naloxone, not diprenorphine, and is always prepared before the preparation of etorphine to be immediately administered following accidental human exposure to etorphine. The LD50 in humans is 3 μg [citation needed] which led to the requirement that the medicine include an equivalent dose of an antidote.
One of its main advantages is its speed of operation, and more importantly, the speed that diprenorphine reverses its effects. The high incidence of side effects, including severe cardiopulmonary depression, has caused etorphine to fall into disfavor in general veterinary practice. However, its high potency, combined with the rapid action of both etorphine and its antagonist, diprenorphine, means that it has found a place for use in the capture of large mammals, such as rhinoceroses and elephants, where rapid onset and rapid recovery are both very important. The high potency of etorphine means that sufficient etorphine can be administered to large wild mammals by projectile syringe (dart). Buy Etorphine (M99) powder
Large Animal Immobilon is a combination of etorphine plus acepromazine maleate. An etorphine antidote Large Animal Revivon contains mainly diprenorphine for animals and a human-specific naloxone-based antidote, which should be prepared prior to the etorphine. A 5–15 mg dose is enough to immobilise an African elephant and a 2–4 mg dose is enough to immobilise a black rhinoceros.[5]
Pharmacology
Etorphine is a potent, non-selective full agonist of the μ-, δ-, and κ-opioid receptors.[6][7] It has a weak affinity for the nociceptin receptor.
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Etorphine (M99) Powder
Etorphine (M99) Powder is a full opiate agonist and binds to multiple opiate sites in the central nervous system. It is believed to produce its clinical
effects through binding the µ-, δ-, and κ- opiate sites.
Etorphine (M99) Powder has a potent effect on depressing the respiratory centers of the CNS thus resulting in apnea being commonly seen in
immobilized animals.
Etorphine (M99) Powder is chemically related to morphine. In laboratory animals, etorphine resembles morphine by causing analgesia, catatonia,
blockade of conditional reflexes, and anti-diuretic effect. It also resembles morphine by causing excitement in mice, cats and bradycardia and
hypotension in rats, dogs, cats and monkeys. When given subcutane- ously, etorphine is 1000-4000 times more potent than morphine as an analgesic,
depending on the test situation. Its use for immobilizing game animals results largely from its ability to cause catatonia at very low dose levels.
The chemical name for etorphine hydrochloride is 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-3-hydroxy-6-methoxy-ά,17-dimethyl-ά-propyl-,
(5ά,7á-(R))- hydrochloride.
The approved generic name for this compound is diprenorphine, and the chemical name is N-cyclopropylmethyl-6, 14-endoetheno-7-(1-hydroxy-1-
methylethyl)tetrahydro-nororipavine. It is a potent morphine antagonist with an action similar to nalorphine. Its potency, however, was stated by
Bentley et al. (1965) to be up to 35 times greater than nalorphine and to have a duration of action two to three times as long. In game animals it
produced a rapid and complete reversal of the immobilisation produced by M99. Although it appears that there may be some degree of species
variation in the response in practice it has been found that a dosage ratio M5050 to M99 of 1:1 is perfectly satisfactory i.e. 1.3mg diprenorphine
produces reversal of the immobilising action of 1mg etorphine.
Safety Precautions
Keep M99 and M5050 together.
Ensure that there is sufficient M5050 to reverse the effects of M99.
Load the M5050 syringe first and keep it to hand throughout the procedure.
Load the M99 syringe well clear of the patient or assisting persons.
Use a disposable syringe.
Discard empty M99/M5050 vials – never reuse containers for other drugs.
Always ensure that a syringe loaded with an appropriate antidote for human use is at hand (Narcan).
DON’T confuse different preparations.
DON’T use a syringe that has previously been used for M99 or any other drugs.
DON’T carry a syringe loaded with M99 in your pocket. Syringes loaded with M99 should carry a needle guard.
Further advice on handling Large Animal M99
Once the required dose of M99 has been withdrawn from the vial it is strongly recommended that the needle be removed from the syringe and
discarded into a closed container. A sterile needle should then be inserted into the injection site and the syringe connected to it.
Wear gloves.
Do not pressurise the contents of the vial.
An eye and skin wash should be made available.
An assistant capable of giving an injection of reversing agent should be present whenever Large Animal M99 is used.
The veterinary surgeon should fully brief the assistant on the procedure and indicate whether M5050 is to be considered as an antidote in the event of
personal accident.
To minimise risk of accident when injecting M99 i.v., the Portex Minivein or similar equipment can be used.
Immobilise only one animal at a time and keep it under constant supervision at all stages. In cases of respiratory failure, inject M5050 immediately and
maintain artificial ventilation.
Accident Procedure
M99 is a very potent neuroleptanalgesic which is highly toxic in man. It causes dizziness, nausea and pinpoint pupils, followed by respirator
If there is any danger that M99 may have been injected or absorbed, the following steps should be taken IMMEDIATELY!!!!! In case of:
Accidental injection (including needle scratch).
Splashing into eyes, mouth or nose.
Spillage on to the skin or immediate clothing.
BEFORE CALLING MEDICAL ASSISTANCE, INJECT A REVERSING AGENT. In case of 1) or 2), immediate washing with plenty of water may prevent
significant absorption, but THIS SHOULD NEVER BE ASSUMED. THE DATA SHEET OR PACK LEAFLET SHOULD BE HANDED TO THE ATTENDING DOCTOR.
Reversing Agents
Inject 2-3mls Narcan (0.4mg/ml naloxone) preferably intravenously or alternatively intramuscularly, and repeat at intervals of 2 to 3 minutes until
symptoms are reversed. In the event of Narcan being unavailable, or in a situation of extreme emergency, the following information is provided for
possible guidance: Inject 0.1ml M5050 preferably intravenously or alternatively intramuscularly, but if the actual quantity of M99 injected or absorbed
is known inject an equal quantity of M5050. If respiratory depression is not reversed, repeat the dose after 2 or 3 minutes. Recurrence of morphinelike effects may occur due to enterohepatic recycling. (M5050 may also induce a hallucinatory state). IT IS VITAL THAT ADEQUATE RESPIRATION AND
HEARTBEAT BE MAINTAINED, IF NECESSARY BY MEANS OF ARTIFICAL RESPIRATION AND EXTERNAL HEART MASSAGE, UNTIL MEDICAL HELP ARRIVES.
Adequate respiration must be maintained by:
(a) Ensuring that the airway is clear by placing the patient in the recovery position removing dentures or any other oral obstruction, and
(b) applying artifical ventilation if breathing has stopped altogether. The mouth-to-mouth technique is usually the only one applicable in the
circumstances
Buy Etorphine Powder Online
Buy Etorphine Powder Online (M99) is a semi-synthetic opioid possessing an analgesic potency approximately 1,000–3,000 times that of morphine. Etorphine Powder for sale
Veterinary use
Buy Etorphine Online is available legally only for veterinary use and is strictly governed by law. It is often used to immobilize elephants and other large mammals. Diprenorphine (Revivon) is an opioid vantagonist that can be administered in proportion to the amount of etorphine used (1.3 times) to reverse its effects.
Veterinary-strength etorphine is fatal to humans. Order Etorphine Powder Online For this reason the package as supplied to vets always includes the human antidote as well as etorphine.
The human antidote is generally naloxone, not diprenorphine, and is always prepared before the preparation of etorphine to be immediately administered following accidental human exposure to etorphine. Order Etorphine Powder Online The LD50 in humans is 30 μg which led to the requirement that the medicine include an equal dose of an antidote, diprenorphine or naloxone.
One of its main advantages is its speed of operation, and more importantly, the speed that diprenorphine reverses its effects. Buy Etorphine Powder Online The high incidence of side effects, including severe cardiopulmonary depression, has caused etorphine to fall into disfavor in general veterinary practice.
Legal status | Obtain Etorphine Powder Online
In Hong Kong, etorphine is regulated under Schedule 1 of Hong Kong’s Chapter 134 Dangerous Drugs Ordinance. Buy Etorphine Powder Online It can be used legally only by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. Buy Etorphine Online
Anyone who supplies the substance without prescription can be fined $10,000 (HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time.
In the Netherlands, etorphine is a list I drug of the Opium Law. Etorphine Powder for sale online It is used only for veterinary purposes in zoos to immobilize large animals. Buy Etorphine Online
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